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"Forty-Six & 2" is a song by American band Tool from their 1996 album Ænima. It was also released in the form of a promo single, and received radio airplay.

Since the Ænima tour, Tool has performed "Forty-Six & 2" at nearly every show.

Title and lyrics

The title references an idea first conceived by Drunvalo Melchizedek concerning the possibility of reaching a state of evolution at which the body would have two more than the normal 46 total chromosomes and leave a currently disharmonious state. The premise is that humans would deviate from the current state of human DNA which contains 44 chromosomes and 2 sex autosomes . The next step of evolution would likely have 46 and 2 chromosomes in their DNA.

Furthermore, the song references a wish to experience change through the "shadow"; an idea which represents the parts of one's personality that one hates and fears, which also exists as a recurring theme in the work of Carl Jung.

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